Inhibition by aspirin of ribose conjugation in the metabolism of histamine.

@article{Beaven1974InhibitionBA,
  title={Inhibition by aspirin of ribose conjugation in the metabolism of histamine.},
  author={M. A. Beaven and Z. Hor{\'a}kov{\'a} and H. Keiser},
  journal={European journal of pharmacology},
  year={1974},
  volume={29 1},
  pages={
          138-46
        }
}
Abstract In man and rats, aspirin and sodium salicylate inhibit the conjugation of ribose to imidazole acetic acid, one of the reactions in the metabolism of histamine. Inhibition occurs with small, therapeutic doses of aspirin but does not occur with the administration of non-salicylate anti-inflammatory agents. Aspirin appears to affect specifically ribose conjugation; the formation of glucuronide and ethereal sulfate derivatives of estrone and morphine are not blocked by aspirin. Since… 
10 Citations
Effect of salicylates on histamine and L-histidine metabolism. Inhibition of imidazoleacetate phosphoribosyl transferase.
TLDR
The effect of anti-inflammatory drugs on imidazoleacetate phosphoribosyl transferase, the enzyme that catalyzes the ATP-dependent conjugation ofImidazolacetate with phosphorIBosylpyrophosphate, is investigated to determine the locus of salicylate action.
Interference with histamine and imidazole acetic acid metabolism by salicylates: A possible contribution to salicylate analgesic activity?
In man, rats and mice, the urinary excretion of the histamine andl-histidine metabolite, imidazole acetic acid, is increased and that of the conjugated metabolite, ribosylimidazole acetic acid,
INHIBITION OF IMIDAZOLEACETATE PHOSPHORIBOSYL TRANSFERASE
A B ST R A CT In man and other animals, urinary excretion of the histidine and histamine metabolite, imidazoleacetate, is increased and that of its conjugated metabolite, ribosylimidazoleacetate,
Inhibition of histamine methylation in vivo by the Dimaprit analog, SKF compound 91488
The Dimaprit analog,S-[4-(N,N-dimethylamino)-butyl]isothiourea (SKF Compound 91488), which is a noncompetitive inhibitor (Ki, 0.9 μM) of histamine-N-methyl-transferase in vitro, inhibited the
Catabolism of Histamine
The role of histamine in the control of general and local homeostasis is a recent discovery which is undergoing further investigation. The physiological significance of histamine-degrading enzymes as
Evidence for rapid histamine turnover and loss of histamine from immature rat mast cells.
TLDR
It is shown that a substantial proportion of newly formed histamine in young mast cells leaked to the extracellular environment, a possible indication that the supply of intracellular histidine was sufficient to maintain normal histamine synthetic activity.
Treatment of urticaria.
  • J. Guin
  • Medicine
    The Medical clinics of North America
  • 1982
TLDR
Treatment of both acute and chronic urticaria necessitates removal of the patient from aggravating factors as well as the cause of the outbreak (if one can be found), along with effective antihistaminic agents and perhaps beta 2-adrenergic agonists.

References

SHOWING 1-10 OF 32 REFERENCES
Metabolism of C14 histamine in man.
TLDR
Three normal men were injected intradermally with microgram quantities of C14 histamine, and analysis of this urine showed that 1-methylimidazole-4-acetic acid is the principal metabolite.
Metabolism of drugs. LXIX. Studies on the urinary metabolites of morphine in several mammlian species.
TLDR
It is demonstrated that morphine is common in rabbits, guinea pigs, rats, mice and human, and as a minor metabolite of morphine, normorphine was also detected in the urine samples of these species by thin-layer chromatography.
THE APPLICATION OF PAPER PARTITION CHROMATOGRAPHY TO THE STUDY OF THE METABOLISM OF SALICYLATE IN THE RAT
TLDR
The metabolism of salicylate in the rat has been investigated by a paper chromatographic method which gave a complete separation of the known metabolites which were quantitatively estimated.
Increase in histidine decarboxylase activity of rat skin following treatment with compound 48/80.
TLDR
It seems probable that 48/80 treatment leads to the production of new, resistant mast cells which are particularly active in forming histamine, and this speculation is compatible with reports from other laboratories of histological studies on rats given 48/ 80.
Inhibition of enzymes by alkylsalicylic acids
TLDR
The comparable results with a trinitrobenzaldehyde reagent suggest that the various inhibitions arise by non‐specific association of the drugs with arginine and lysine residues in proteins.
Pharmacological modification of glutathione and NADP+ reduction.
TLDR
The main interest in these agents has been to elucidate the hemolytic mechanism they induce in sensitive enzyme-deficient cells.
Salicylate and enzymes
TLDR
Reported inhibitory actions of the salicylate ion on important enzyme systems in vitro are reviewed and assessed in relation to the known clinical and toxic effects of the drug.
Species difference in the structure of urinary 2-hydroxyestrone glucuronide.
Abstract Metabolism of radioactive estrone by female rats and hamsters leads to excretion of urinary 2-hydroxyestrone conjugated with “glucuronic acid” exclusively at the 2 position. Simular
Effects of salicylate on the incorporation of orotic acid into nucleic acids of mouse tissues in vivo
TLDR
In mice, given intraperitoneal injections of orotic acid‐5‐3H, two peaks of incorporation of radioactivity at 30 min and 6 h occurred in the RNA of kidney and of liver and its subcellular components, and the concurrent administration of salicylate significantly inhibited the incorporation of the labelled orotics acid.
Acetylsalicylic acid--induced hemolysis and its mechanism.
TLDR
It is suggested that enzyme inhibition by salicylate and gentisate may play an important role in ASA-induced hemolysis, which would further curtail NADPH regeneration, rendering the cells more vulnerable to oxidants.
...
1
2
3
4
...