Inhibition by apomorphine of the metoclopramide-induced catalepsy and increase in striatal homovanillic acid content.

@article{Ahtee1975InhibitionBA,
  title={Inhibition by apomorphine of the metoclopramide-induced catalepsy and increase in striatal homovanillic acid content.},
  author={Liisa Ahtee},
  journal={British journal of pharmacology},
  year={1975},
  volume={55 3},
  pages={381-5}
}
  • Liisa Ahtee
  • Published 1975 in British journal of pharmacology
1 The mechanism of the cataleptic effect of metoclopramide was analyzed by using drugs which alter the activity of dopaminergic or cholinergic neurones or the content of psi-aminobutyric acid in the central nervous system of rats. 2 The cataleptic effect of metoclopramide (20 mg/kg) was antagonized by apomorphine (10 mg/kg) and by atropine (50 mg/kg). Aminoxyacete acid (AOAA, 25-50 mg/kg) potentiated the catalepsy induced by metoclopramide (5 mg/kg). 3 Metoclopramide alone did not alter the… CONTINUE READING