Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes

@article{Venance1995InhibitionBA,
  title={Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes},
  author={Laurent Venance and Daniele Piomelli and Jacques Glowinski and Christian Glaume},
  journal={Nature},
  year={1995},
  volume={376},
  pages={590-594}
}
ANANDAMIDE, an endogenous arachidonic acid derivative that is released from neurons and activates cannabinoid receptors1, may act as a transcellular cannabimimetic messenger in the central nervous system2–4. The biological actions of anandamide and the identity of its target cells are, however, still poorly documented5. Here we show that anandamide is a potent inhibitor of gap-junction conductance and dye permeability in striatal astrocytes. This inhibitory effect is specific for anandamide as… CONTINUE READING
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