• Medicine
  • Published in
    European journal of cancer…
    1997

Inhibition by acetaminophen of intestinal cancer in rats induced by an aromatic amine similar to food mutagens.

@article{Williams1997InhibitionBA,
  title={Inhibition by acetaminophen of intestinal cancer in rats induced by an aromatic amine similar to food mutagens.},
  author={Gary M Williams and Michael J. Iatropoulos},
  journal={European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation},
  year={1997},
  volume={6 4},
  pages={
          357-62
        }
}
The widely used analgesic acetaminophen (APAP) was studied in rats for its ability to inhibit intestinal carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB), which was selected as the carcinogen because of its similarity to the heterocyclic amines formed during cooking and which are postulated to be involved in colon cancer in humans. APAP was fed to male F344 rats at 250 ppm, which is about 1/4 the human therapeutic dose and at 5000 ppm, which is about fivefold the human dose. DMAB… CONTINUE READING