Inhibition by Theanine of Binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to Glutamate Receptors

  title={Inhibition by Theanine of Binding of [3H]AMPA, [3H]Kainate, and [3H]MDL 105,519 to Glutamate Receptors},
  author={T. Kakuda and A. Nozawa and A. Sugimoto and H. Niino},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={2683 - 2686}
  • T. Kakuda, A. Nozawa, +1 author H. Niino
  • Published 2002
  • Biology, Medicine
  • Bioscience, Biotechnology, and Biochemistry
  • In an investigation of the mechanisms of the neuroprotective effects of theanine (γ-glutamylethylamide) in brain ischemia, inhibition by theanine of the binding of [3H](RS)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, and [3H](E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1-H-indole-2-carboxylic acid (MDL 105,519) to glutamate receptors was studied in terms of its possible inhibiting effects on the three receptor subtypes (AMPA, kainate, and NMDA glycine), with rat… CONTINUE READING
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