Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide.

@article{Robertson1993InhibitionBS,
  title={Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide.},
  author={Iain G. C. Robertson and T J Bland},
  journal={Biochemical pharmacology},
  year={1993},
  volume={45 10},
  pages={
          2159-62
        }
}
An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes.
TLDR
This in vitro study was designed to identify the enzyme(s) involved in the two major metabolic pathways of rokitamycin and to assess possible drug interactions using human liver microsomes and it was concluded that the formations of LMA7 from rokit amycin and of LMV from L MA7 are catalyzed mainly by human esterase enzyme.
Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications
TLDR
It is proposed that M11 is likely involved in the observed obstructive nephropathy reported in clinical studies, and illustrates the need to conduct thorough metabolic evaluations early in drug development to select the most relevant nonclinical species for toxicological evaluation.
Presence and ex vivo formation of acridone in blood of patients routinely treated with carbamazepine: exploration of the 9-acridinecarboxaldehyde pathway
TLDR
AO might be considered as a metabolite of 9-acridinecarboxaldehyde that does not react with cells (detoxicant pathway) as well as a marker of the formation of toxic AI derivatives (t toxicant pathway).
DNA-intercalating Analogues [ 2-( Dimethylamino ) ethyl ] acridine-4-carboxamide and N-Carbon-11-labeled Comparative Biodistribution and Metabolism of Updated Version
TLDR
By using a strategy with C-labeling, the tissue distribution and metabolic stability of novel tricyclic carboxamides are determined with the view of selecting analogues with potentially better in vivo activity against solid tumors.
Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues.
TLDR
By using a strategy with 11C-labeling, the tissue distribution and metabolic stability of novel tricyclic carboxamides are determined with the view of selecting analogues with potentially better in vivo activity against solid tumors.
Metabolism of N -[2-(dimethylamino)ethyl]acridine-4-carboxamide in cancer patients undergoing a phase I clinical trial
TLDR
The results indicate that, based on urinary excreted metabolites, the major biotransformation reactions for DACA in humans involve N-oxidation of the tertiary amine side chain and acridone formation, both of which appear to be detoxication reactions.
Tissue distribution and biotransformation of potassium oxonate after oral administration of a novel antitumor agent (drug combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) to rats.
TLDR
Oxo was mainly distributed to the intracellular sites of the small intestines in a much higher concentration than 5-FU and that little was distributed to other tissues, including tumors, which concludes that this is the reason why Oxo suppresses the GI toxicity of5-FU without affecting its antitumor activity.
Investigation of aldehyde oxidase and xanthine oxidoreductase in rainbow trout (Oncorhynchus mykiss)
TLDR
New insight is yielded into groups of anthropogenic environmental pollutants, drugs and vitamins that are substrates and inhibitors of an ancestral vertebrate AOX.
Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices
  • A. Renwick, S. Ball, B. Lake
  • Biology, Chemistry
    Xenobiotica; the fate of foreign compounds in biological systems
  • 2002
TLDR
Cimetidine appears to be a more potent inhibitor of aldehyde oxidase than of CYP3A forms and hence in vivo is likely to have a more marked effect on ZAL metabolism to M2 than on DZAL formation.
...
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