Inhibition by L-NA, a nitric oxide synthase inhibitor, of naloxone-precipitated withdrawal signs in a mouse model of cholestasis.

@article{Ghafourifar1997InhibitionBL,
  title={Inhibition by L-NA, a nitric oxide synthase inhibitor, of naloxone-precipitated withdrawal signs in a mouse model of cholestasis.},
  author={Pedram Ghafourifar and Ahmad R Dehpour and Nasrin Akbarloo},
  journal={Life sciences},
  year={1997},
  volume={60 19},
  pages={
          PL 265-70
        }
}
Following the naloxone administration in bile duct resected animals, striking opioid withdrawal signs are observed due to increased opioidergic tone. Pretreatment of animals with L-nitro arginine, a nitric oxide synthase inhibitor, reduces the naloxone-precipitated withdrawal signs as well as increase the antinociception. The results of this study support… CONTINUE READING