Inhibition by KF17837 of adenosine A2A receptor-mediated modulation of striatal GABA and ACh release.

@article{Kurokawa1994InhibitionBK,
  title={Inhibition by KF17837 of adenosine A2A receptor-mediated modulation of striatal GABA and ACh release.},
  author={Mamoru Kurokawa and Ian P Kirk and K. A. Kirkpatrick and Hiroshi Kase and Peter J. Richardson},
  journal={British journal of pharmacology},
  year={1994},
  volume={113 1},
  pages={43-8}
}
1. The effect of the A2A adenosine receptor agonist, 2-p-(2-carboxyethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS 21680) on the potassium evoked release of [3H]-gamma-aminobutyric acid ([3H]-GABA) from nerve terminals derived from the caudate-putamen and the globus pallidus of the rat was compared. In both preparations CGS 21680 (1 nM) inhibited the [3H]-GABA release evoked by 15 mM KCl but had no effect on that evoked by 30 mM KCl. 2. The ability of CGS 21680 (1 nM) to inhibit the… CONTINUE READING