Inhibition and induction of rabbit liver microsomal cytochrome P-450 by pyridine.

@article{Kaul1987InhibitionAI,
  title={Inhibition and induction of rabbit liver microsomal cytochrome P-450 by pyridine.},
  author={K L Kaul and Raymond F. Novak},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={243 1},
  pages={384-90}
}
The effects of acute and chronic administration of pyridine (PY) on rabbit hepatic microsomal cytochrome P-450-catalyzed drug metabolism have been examined. PY inhibited cytochrome P-450-catalyzed drug metabolism in vitro and in vivo. Noncompetitive inhibition of microsomal drug metabolism was observed with inhibitory constant (Ki) values ranging between 2… CONTINUE READING