Inhibition and induction of human cytochrome P450 enzymes: current status

  title={Inhibition and induction of human cytochrome P450 enzymes: current status},
  author={Olavi Pelkonen and Miia Turpeinen and Jukka Hakkola and Paavo Honkakoski and Janne Hukkanen and Hannu Raunio},
  journal={Archives of Toxicology},
Variability of drug metabolism, especially that of the most important phase I enzymes or cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of pharmacology and toxicology, in drug development, preclinical toxicity studies, clinical trials, drug therapy, environmental exposures and risk assessment. These frequently enormous consequences in mind, predictive and pre-emptying measures have been a top priority in both pharmacology and toxicology. This means the… CONTINUE READING
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