Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells.

@article{Canton2005InhibitionAI,
  title={Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells.},
  author={Rocio Fernandez Canton and J Thomas Sanderson and Robert J Letcher and {\AA}ke Lennart Bergman and Martin H Van Den Berg},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={88 2},
  pages={447-55}
}
Brominated flame retardants (BFRs) are persistent and ubiquitous chemicals in the environment, and they are found at increasing levels in tissues of wildlife and humans. Previous in vitro studies with the BFR class of polybrominated diphenyl ethers (BDEs) have shown endocrine-disrupting properties. Our study assessed the potential effects of nineteen BDEs, five hydroxylated BDEs (OH-BDEs), one methoxylated BDE (CH(3)O-BDE), tetrabromobisphenol-A (TBBPA), its dibromopropane ether derivative… CONTINUE READING
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