Inhibiting vasculogenesis after radiation: a new paradigm to improve local control by radiotherapy.

@article{Martin2013InhibitingVA,
  title={Inhibiting vasculogenesis after radiation: a new paradigm to improve local control by radiotherapy.},
  author={Brown J Martin},
  journal={Seminars in radiation oncology},
  year={2013},
  volume={23 4},
  pages={
          281-7
        }
}
Tumors are supported by blood vessels, and it has long been debated whether their response to irradiation is affected by radiation damage to the vasculature. We have shown in preclinical models that, indeed, radiation is damaging to the tumor vasculature and strongly inhibits tumor angiogenesis. However, the vasculature can recover by colonization from circulating cells, primarily proangiogenenic CD11b+ monocytes or macrophages from the bone marrow. This secondary pathway of blood vessel… CONTINUE READING

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