Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

@article{Parone2006InhibitingTM,
  title={Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.},
  author={Philippe A. Parone and Dominic I. James and Sandrine Da Cruz and Yves Mattenberger and Olivier Donz{\'e} and François Barja and J C Martinou},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 20},
  pages={7397-408}
}
Apoptosis, induced by a number of death stimuli, is associated with a fragmentation of the mitochondrial network. These morphological changes in mitochondria have been shown to require proteins, such as Drp1 or hFis1, which are involved in regulating the fission of mitochondria. However, the precise role of mitochondrial fission during apoptosis remains elusive. Here we report that inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the… CONTINUE READING

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