Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun.

@article{Itamochi2011InhibitingTM,
  title={Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun.},
  author={Hiroaki Itamochi and Tetsuro Oishi and Muneaki Shimada and Shinya Sato and Kazunori Uegaki and Jun Naniwa and Seiya Sato and Michiko Nonaka and Naoki Terakawa and Junzo Kigawa and Tasuku Harada},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 14},
  pages={4742-50}
}
PURPOSE The mTOR pathway is thought to be a central regulator of proliferation and survival of cells. Rapamycin and its analogs are undergoing clinical trials in patients with epithelial ovarian cancer. This study aimed to assess the potential to use rapamycin and anticancer agents in combination for first- and second-line chemotherapy to treat ovarian cancer. EXPERIMENTAL DESIGN We used six ovarian serous adenocarcinoma cell lines (KF, KOC-2S, SHIN-3, SK-OV-3, TU-OS-3, and TU-OS-4) in this… CONTINUE READING

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