Inhibiting the inflammasome: one domain at a time.

  title={Inhibiting the inflammasome: one domain at a time.},
  author={Andrea Dorfleutner and Lan Chu and Christian Stehlik},
  journal={Immunological reviews},
  volume={265 1},
Inflammasomes are protein complexes that promote the maturation and release of pro-inflammatory cytokines and danger signals as well as pyroptosis in response to infections and cellular stress. Inflammasomes consist of a sensor, an adapter, and the effector caspase-1, which interact through homotypic interactions of caspase recruitment domains (CARDs) or PYRIN domains (PYDs). Hence, decoy proteins encoding only a CARD or PYD, COPs and POPs, respectively, are assumed to inhibit inflammasome… CONTINUE READING
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