Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells.

@article{Lub2016InhibitingTA,
  title={Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells.},
  author={Susanne Lub and Anke Maes and Ken Maes and Kim De Veirman and Elke De Bruyne and Eline Menu and Karel Fostier and Alboukadel Kassambara and J{\'e}r{\^o}me Moreaux and Dirk Hose and Xavier Leleu and Randall W. King and Karin Vanderkerken and Els Van Valckenborgh},
  journal={Oncotarget},
  year={2016},
  volume={7 4},
  pages={4062-76}
}
The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance and therapeutic potential of APC/C and its co-activator Cdc20 in multiple myeloma (MM). Gene expression analysis revealed that Cdc20 was expressed at higher levels in gene expression-based high-risk MM patients. Moreover, high Cdc20 expression correlated with poor prognosis… CONTINUE READING
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