Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

@article{SeegerNukpezah2013InhibitingTH,
  title={Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.},
  author={Tamina N Seeger-Nukpezah and David A. Proia and Brian L. Egleston and Anna S. Nikonova and Tatiana Kent and Kathy Qi Cai and Harvey Hensley and Weiwen Ying and Dinesh Chimmanamada and Ilya G. Serebriiskii and Erica A Golemis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 31},
  pages={12786-91}
}
Autosomal dominant polycystic kidney disease (ADPKD) is a progressive genetic syndrome with an incidence of 1:500 in the population, arising from inherited mutations in the genes for polycystic kidney disease 1 (PKD1) or polycystic kidney disease 2 (PKD2). Typical onset is in middle age, with gradual replacement of renal tissue with thousands of fluid-filled cysts, resulting in end-stage renal disease requiring dialysis or kidney transplantation. There currently are no approved therapies to… CONTINUE READING
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