Inhibiting proteasome activity causes overreplication of DNA and blocks entry into mitosis in sea urchin embryos.

@article{Kawahara2000InhibitingPA,
  title={Inhibiting proteasome activity causes overreplication of DNA and blocks entry into mitosis in sea urchin embryos.},
  author={Hironori Kawahara and Rada Philipova and Hideyoshi Yokosawa and Rajnikant Patel and Keiji Tanaka and Michael Whitaker},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 15)},
  pages={2659-70}
}
The proteasome has been shown to be involved in exit from mitosis by bringing about destruction of mitotic cyclins. Here, we present evidence that the proteasome is also required for proper completion of S phase and for entry into mitosis in the sea urchin embryonic cleavage cycle. A series of structurally related peptide-aldehydes prevent nuclear envelope breakdown in their order of inhibitory efficacies against the proteasome. Their efficacies in blocking exit from S phase and exit from… CONTINUE READING

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