Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling.

@article{Strande2007InhibitingPR,
  title={Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling.},
  author={Jennifer L Strande and Anna K. Hsu and Jidong Su and Xiangping Fu and Garrett Gross and John E Baker},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={324 3},
  pages={
          1045-54
        }
}
Harnessing endogenous cardioprotectants is a novel therapeutic strategy to combat ischemia/reperfusion (I/R) injury. Thrombin causes I/R injury, whereas exogenous adenosine prevents I/R injury. We hypothesized that blocking thrombin receptor activation with a protease-activated receptor (PAR) 4 antagonist would unmask the cardioprotective effects of endogenous adenosine. The protective role of two structurally unrelated PAR4 antagonists, trans-cinnamoyl-YPGKF-amide (tc-Y-NH(2)) and palmitoyl… CONTINUE READING

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