Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors

@article{Rhodes2001InhibitingPM,
  title={Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors},
  author={M. Rhodes and C. Frye},
  journal={Cognitive, Affective, & Behavioral Neuroscience},
  year={2001},
  volume={1},
  pages={287-296}
}
  • M. Rhodes, C. Frye
  • Published 2001
  • Psychology, Medicine
  • Cognitive, Affective, & Behavioral Neuroscience
  • Blocking progesterone’s metabolism to 5α -pregnan-3α -ol-20-one (3α ,5α -THP) with finasteride, a 5α -reductase inhibitor, and effects on anxiolytic, exploratory, and antinociceptive behaviors of rats in behavioral estrus were examined. Rats in behavioral estrus received finasteride systemically (SC), to the hippocampus, or to control implant sites, the nucleus accumbens (NA) or ventral tegmental area (VTA), and were tested in horizontal crossing, open-field, elevated plus-maze, emergence… CONTINUE READING
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