Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.

@article{Hausenloy2003InhibitingMP,
  title={Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.},
  author={Derek Hausenloy and Michael R Duchen and Derek M Yellon},
  journal={Cardiovascular research},
  year={2003},
  volume={60 3},
  pages={617-25}
}
OBJECTIVE The opening of the mitochondrial permeability transition pore (mPTP) in the first few minutes of post-ischaemic reperfusion is a critical determinant of reperfusion-induced cell death. We hypothesised that the novel immunosuppressant, sanglifehrin-A (SFA), given at the time of reperfusion, protects the myocardium from ischaemia-reperfusion injury, by suppressing mPTP opening. METHODS Isolated perfused rat hearts were subjected to 35 min ischaemia/120 min reperfusion, and were… CONTINUE READING

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