Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.

@article{Zhao2007InhibitingGS,
  title={Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.},
  author={Hongmei Zhao and Malgorzata Przybylska and I-Huan Wu and Jinhua Zhang and Craig Siegel and Svetlana Komarnitsky and Nelson S. Yew and Seng H. Cheng},
  journal={Diabetes},
  year={2007},
  volume={56 5},
  pages={1210-8}
}
Previous reports have shown that glycosphingolipids can modulate the activity of the insulin receptor, and studies in transgenic mice suggest a link between altered levels of various gangliosides and the development of insulin resistance. Here, we show that an inhibitor of glycosphingolipid synthesis can improve glucose control and increase insulin sensitivity in two different diabetic animal models. In the Zucker diabetic fatty rat, the glucosylceramide synthase inhibitor (1R,2R)-nonanoic acid… CONTINUE READING

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