Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.

@article{Zhao2009InhibitingGS,
  title={Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.},
  author={Hongmei Zhao and Malgorzata Przybylska and I-Huan Wu and Jinhua Zhang and Panagiotis Maniatis and Joshua Pacheco and Peter A. Piepenhagen and David S. Copeland and Cynthia M. Arbeeny and James A. Shayman and Johannes M F G Aerts and Canwen Jiang and Seng H. Cheng and Nelson S. Yew},
  journal={Hepatology},
  year={2009},
  volume={50 1},
  pages={
          85-93
        }
}
UNLABELLED Steatosis in the liver is a common feature of obesity and type 2 diabetes and the precursor to the development of nonalcoholic steatohepatitis (NASH), cirrhosis, and liver failure. It has been shown previously that inhibiting glycosphingolipid (GSL) synthesis increases insulin sensitivity and lowers glucose levels in diabetic rodent models. Here we demonstrate that inhibiting GSL synthesis in ob/ob mice not only improved glucose homeostasis but also markedly reduced the development… CONTINUE READING
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