Inhibiting gene expression in vivo by virus-mediated small interfering RNA

@article{Wang2008InhibitingGE,
  title={Inhibiting gene expression in vivo by virus-mediated small interfering RNA},
  author={Ping Yu Wang and Shu-yang Xie and Anfang Cui and Fei Peng Jiao and Zhi Liang Li and Xiao Yan Bai and Feng Liu},
  journal={Molecular Biology},
  year={2008},
  volume={42},
  pages={888-893}
}
Inhibiting gene expression in specific tissues and organs through intravenous injection would be the ultimately preferred method of disease therapy. Here, we report the successful delivery of lentivirus-mediated small interfering RNA (siRNA) to suppress GFP gene expression in living mice. First, a lentiviral vector with siRNA (len-siRNA) driven by H1… CONTINUE READING