Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells.

@article{Li1999InhibitingGJ,
  title={Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells.},
  author={Zhongyong Li and Zhiyi Zhou and Clare E. Yellowley and Henry J. Donahue},
  journal={Bone},
  year={1999},
  volume={25 6},
  pages={
          661-6
        }
}
Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenotypic characteristics of fully differentiated osteoblasts. We utilized ROS rendered communication deficient either by stable transfection with antisense cDNA to connexin 43 (Cx43… CONTINUE READING
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