Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.

@article{Cohen2007InhibitingAG,
  title={Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.},
  author={Margo Panush Cohen and Gregory T Lautenslager and Elizabeth A Hud and Elizabeth A Shea and Amy Wang and Sheldon Chen and Clyde W. Shearman},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 2},
  pages={F789-95}
}
Glomerular cells in culture respond to albumin containing Amadori glucose adducts (the principal serum glycated protein), with activation of protein kinase C-beta(1), increased expression of transforming growth factor (TGF)-beta1, the TGF-beta type II signaling receptor, and the extracellular matrix proteins alpha(1)(IV) collagen and fibronectin and with decreased production of the podocyte protein nephrin. Decreasing the burden of glycated albumin in diabetic db/db mice significantly reduces… CONTINUE READING

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