Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization.

@article{Paletzki2008InhibitingAP,
  title={Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization.},
  author={Ronald F. Paletzki and Maxim V Myakishev and Oksana Polesskaya and Adrienn Orosz and Steven E Hyman and Charles Vinson},
  journal={Neuroscience},
  year={2008},
  volume={152 4},
  pages={1040-53}
}
We have expressed A-FOS, an inhibitor of activator protein-1 (AP-1) DNA binding, in adult mouse striatal neurons. We observed normal behavior including locomotion and exploratory activities. Following a single injection of cocaine, locomotion increased similarly in both the A-FOS expressing and littermate controls. However, following repeated injections of cocaine, the A-FOS expressing mice showed increased locomotion relative to littermate controls, an increase that persisted following a week… CONTINUE READING