Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis

  title={Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis},
  author={Aleena Banerji and Paula J Busse and Mustafa Shennak and William R Lumry and Mark A Davis-Lorton and H. James Wedner and Joshua J. Jacobs and James Baker and Jonathan A. Bernstein and Richard F. Lockey and Henry H. Li and Timothy Craig and Marco Cicardi and Marc A. Riedl and Ahmad Al-Ghazawi and Carolyn Soo and Ryan Iarrobino and Daniel J. Sexton and Christopher Tenhoor and Jon A. Kenniston and Ryan R. Faucette and Gordon J. Still and Harvey W Kushner and Robert K. Mensah and Chris Stevens and Joseph C. Biedenkapp and Yung H Chyung and Burt Adelman},
  journal={The New England Journal of Medicine},
Background Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high‐molecular‐weight kininogen. Lanadelumab (DX‐2930) is a new kallikrein inhibitor with the potential for prophylactic treatment of hereditary angioedema with C1 inhibitor deficiency. Methods We conducted a phase 1b, multicenter, double‐blind, placebo… 

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