Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration.

  title={Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration.},
  author={Jodie Daniels and A. Binch and Christine Lyn Le Maitre},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={35 1},
Intervertebral disc degeneration is characterized by an imbalance between catabolic and anabolic signaling, with an increase in catabolic cytokines particularly IL-1β, a key regulator of IVD degeneration. This study aimed to investigate intracellular signaling pathways activated by IL-1β, and GDF-5 in the degenerate IVD to identify potential new therapeutic targets. Human NP cells were cultured in alginate beads to regain in vivo phenotype prior to stimulation with IL-1β or GDF-5 for 30 min, a… CONTINUE READING
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