Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks

@inproceedings{Dong2017InhibitingDI,
  title={Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks},
  author={Jun Dong and Tian Zhang and Yufeng Ren and Zhenyu Wang and C. Clifton Ling and Fuqiu He and Gloria C. Li and Chengtao Wang and Bixiu Wen},
  booktitle={Oncotarget},
  year={2017}
}
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a distinct factor in the non-homologous end-joining (NHEJ) pathway involved in DNA double-strand break (DSB) repair. We examined the crosstalk between key proteins in the DSB NHEJ repair pathway and cell cycle regulation and found that mouse embryonic fibroblast (MEF) cells deficient in DNA-PKcs or Ku70 were more vulnerable to ionizing radiation (IR) compared with wild-type cells and that DSB repair was delayed. γH2AX was associated… CONTINUE READING

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