Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation.

@article{Langenfeld1996InhibitedTO,
  title={Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation.},
  author={John Langenfeld and Fulvio Lonardo and Hiroaki Kiyokawa and Tina Passalaris and Myung Ju Ahn and Valerie M Rusch and Ethan Dmitrovsky},
  journal={Oncogene},
  year={1996},
  volume={13 9},
  pages={1983-90}
}
The retinoids are reported to reduce second primary aerodigestive tract tumors in patients with prior lung or head and neck carcinomas. Yet, the optimal retinoid useful for chemoprevention and those mechanisms linked to this chemoprevention are not identified. This study reports an in vitro model for carcinogen-induced transformation of immortalized human bronchial epithelial (BEAS-2B) cells that was adapted to study the anti-carcinogenic effects of all-trans-retinoic acid (RA). Following… CONTINUE READING
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