Inhibin and p27 interact to regulate gonadal tumorigenesis.

  title={Inhibin and p27 interact to regulate gonadal tumorigenesis.},
  author={Sherry C Cipriano and Lei Chen and Kathleen H. Burns and Andrew T Koff and Martin M. Matzuk},
  journal={Molecular endocrinology},
  volume={15 6},
Tumor suppressors function as antiproliferative signaling proteins, and defects in these genes lead to uncontrolled cell proliferation and cancer. For example, absence of the tumor suppressor p27(Kip1), a cyclin-dependent kinase inhibitor (CKI), results in increased body size, hyperplasia of several organs including the testes, and cancer in mice. Similarly, lack of inhibins, alpha/beta heterodimeric members of the transforming growth factor-beta (TGFbeta) superfamily, causes testicular and… CONTINUE READING
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Regulatory role of p 27 kip 1 in the mouse and human testis

  • TL Beumer, H Kiyokawa, +6 authors Rooij DGd
  • Endocrinology
  • 1999

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