Inhibin and p27 interact to regulate gonadal tumorigenesis.

@article{Cipriano2001InhibinAP,
  title={Inhibin and p27 interact to regulate gonadal tumorigenesis.},
  author={Sherry C Cipriano and Lei Chen and Kathleen H. Burns and Andrew T Koff and Martin M. Matzuk},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 6},
  pages={985-96}
}
Tumor suppressors function as antiproliferative signaling proteins, and defects in these genes lead to uncontrolled cell proliferation and cancer. For example, absence of the tumor suppressor p27(Kip1), a cyclin-dependent kinase inhibitor (CKI), results in increased body size, hyperplasia of several organs including the testes, and cancer in mice. Similarly, lack of inhibins, alpha/beta heterodimeric members of the transforming growth factor-beta (TGFbeta) superfamily, causes testicular and… CONTINUE READING
24 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Regulatory role of p 27 kip 1 in the mouse and human testis

  • TL Beumer, H Kiyokawa, +6 authors Rooij DGd
  • Endocrinology
  • 1999

Similar Papers

Loading similar papers…