Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy.

@article{Sun2010InheritedVI,
  title={Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy.},
  author={Tong Sun and Gwo-Shu Lee and Lillian L Werner and Mark M Pomerantz and William K Oh and Philip W. Kantoff and Matthew L. Freedman},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2010},
  volume={19 7},
  pages={
          1871-8
        }
}
BACKGROUND Sex steroid hormone receptors mediate essential processes in normal prostate growth and contribute to prostate cancer development. METHOD In this study, we investigated the association between common inherited variation of the AR, ESR1, and ESR2 genes and two clinically relevant traits: the risk of developing aggressive prostate cancer and the response to androgen deprivation therapy (ADT) in a hospital-based cohort. A total of 43 tagging single nucleotide polymorphisms covering… CONTINUE READING

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