Inherited susceptibility to several cancers but absence of linkage between dysplastic nevus syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A (P16INK4A) gene

@article{Puig1997InheritedST,
  title={Inherited susceptibility to several cancers but absence of linkage between dysplastic nevus syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A (P16INK4A) gene},
  author={Susana Puig and Anna Matas Jos{\'e} Luis Raymond Mar Gonz{\'a}lez - Savignat Ad Ruiz and Teresa Castel and V{\'i}ctor Volpini and Josep Malvehy and Francesc Cardellach and Michael Lynch and Jos{\'e} Manuel Mascar{\'o} and Xavier Estivill},
  journal={Human Genetics},
  year={1997},
  volume={101},
  pages={359-364}
}
Genetic predisposition plays an important role in the development of nearly 10% of cases of cutaneous malignant melanoma (CMM). The CDKN2A gene has been described as responsible for melanoma susceptibility in a proportion of families with CMM linked to 9p. CDKN2A encodes a cyclin-dependent kinase inhibitor also implicated in the carcinogenesis of several sporadic tumors. Even though the incidence of other cancers is higher in CMM families, pancreatic adenocarcinoma is the only other well… CONTINUE READING
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Prevalence of germline mutations in p 16 , p 19 ARF , and CDK 4 in familial melanoma : analysis of a clinicbased population

  • MG Fitzgerald, DP Harkin, +8 authors DA Haber
  • Proc Natl Acad Sci USA
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