Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

@article{Bell2005InheritedST,
  title={Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR},
  author={Daphne W Bell and Ira Gore and Ross A. Okimoto and Nadia Godin-Heymann and Raffaella Sordella and Roseann Mulloy and Sreenath V. Sharma and Brian W. Brannigan and Gayatry Mohapatra and Jeffrey Settleman and Daniel A. Haber},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={1315-1316}
}
Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to tyrosine kinase inhibitors. Acquisition of drug resistance is linked to a specific secondary somatic mutation, EGFR T790M. Here we describe a family with multiple cases of non-small cell lung cancer associated with germline transmission of this mutation. Four of six tumors analyzed showed a secondary somatic activating EGFR mutation, arising in cis with the germline EGFR mutation T790M. These… CONTINUE READING
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Allelic analysis of somatic EGFR mutations in lung tumor specimens with germline EGFR T790M Clones

  • C Zhang
  • Nat. Methods
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