Inherited predisposition to glioma.

  title={Inherited predisposition to glioma.},
  author={Athanassios P. Kyritsis and Melissa L Bondy and J. Sunil Rao and Crysoula Sioka},
  volume={12 1},
In gliomas, germline gene alterations play a significant role during malignant transformation of progenitor glial cells, at least for families with occurrence of multiple cancers or with specific hereditary cancer syndromes. Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation. These germline abnormalities are manifested as either gene polymorphisms or hemizygous mutations of key regulatory genes that are… CONTINUE READING
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