Inherited predisposition to colorectal cancer: towards a more complete picture.

@article{Short2015InheritedPT,
  title={Inherited predisposition to colorectal cancer: towards a more complete picture.},
  author={Emma Short and Laura E Thomas and Joanna J Hurley and Sian Jose and Julian R. Sampson},
  journal={Journal of medical genetics},
  year={2015},
  volume={52 12},
  pages={791-6}
}
Colorectal carcinoma (CRC) is the third most common cancer worldwide. Hereditary factors are important in 15%-35% of affected patients. This review provides an update on the genetic basis of inherited predisposition to CRC. Currently known genetic factors include a group of highly penetrant mutant genes associated with rare mendelian cancer syndromes and a… CONTINUE READING