Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.

@article{Dallosso2008InheritedPT,
  title={Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.},
  author={Anthony R. Dallosso and Sunil Dolwani and Natalie C Jones and Sion Jones and James Colley and J. Maynard and Shelley Idziaszczyk and Vikki Humphreys and Julie Arnold and A. L. Donaldson and Diana Eccles and Anthony J Ellis and D Gareth R Evans and Ian M Frayling and Frederik J Hes and Richard S. Houlston and Eamonn R Maher and Maartje Nielsen and Susan Parry and Eleanor M Tyler and Valentina Moskvina and Jeremy P. Cheadle and Julian R. Sampson},
  journal={Gut},
  year={2008},
  volume={57 9},
  pages={1252-5}
}
BACKGROUND MUTYH-associated polyposis (MAP) is a recessive trait characterised by multiple colorectal adenomas and a high risk of colorectal cancer. MUTYH functions in the DNA base excision repair pathway and has a key role in the repair of oxidative DNA damage. OBJECTIVES To assess the contribution of inherited variants in genes involved in base excision repair and oxidative DNA damage including MUTYH, OGG1, NEIL1, NEIL2, NEIL3, NUDT1 and NTH1 to the multiple colorectal adenoma phenotype… CONTINUE READING

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