Inherited human IRAK-4 deficiency: an update.

@article{Picard2007InheritedHI,
  title={Inherited human IRAK-4 deficiency: an update.},
  author={Capucine Picard and Horst von Bernuth and Cheng-Lung Ku and Kun Yang and Anne Puel and J. Hugo P{\'e}rez Casanova},
  journal={Immunologic research},
  year={2007},
  volume={38 1-3},
  pages={
          347-52
        }
}
Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular. 
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