Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

@article{Xu2010InheritedGV,
  title={Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.},
  author={Jianfeng Xu and S{\'i}qun Lilly Zheng and Sarah D. Isaacs and Kathleen E. Wiley and Fredrik Wiklund and Jielin Sun and Andrew Karim Kader and Ge Li and Lina D Purcell and Seong-Tae Kim and Fang-Chi Hsu and P{\"a}r Stattin and Jonas Hugosson and J. Patrik Adolfsson and Patrick Walsh and Jeffrey M. Trent and David Duggan and John D. Carpten and Henrik Gr{\"o}nberg and William B Isaacs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 5},
  pages={2136-40}
}
Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identification of factors specifically associated with risk for more aggressive PCa is urgently needed to reduce overdiagnosis and overtreatment of this common disease. To search for such… CONTINUE READING