Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?

@article{Ghoussaini2013InheritedGS,
  title={Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning?},
  author={Maya Ghoussaini and Paul D P Pharoah and Douglas F. Easton},
  journal={The American journal of pathology},
  year={2013},
  volume={183 4},
  pages={1038-1051}
}
Genome-wide association studies have identified 72 loci associated with breast cancer susceptibility. Seventeen of these are known to predispose to other cancers. High-penetrance susceptibility loci for breast cancer usually result from coding alterations, principally in genes involved in DNA repair, whereas almost all of the associations identified through genome-wide association studies are found in noncoding regions of the genome and are likely to involve regulation of genes in multiple… CONTINUE READING
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Genome-wide association studies identify four ER negative-specific breast cancer risk loci

  • Garcia-ClosasM, FJ Couch, S Lindstrom, K Michailidou, MK Schmidt, MN Brook
  • Nat Genet
  • 2013
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