Inherited epigenetic variation — revisiting soft inheritance

@article{Richards2006InheritedEV,
  title={Inherited epigenetic variation — revisiting soft inheritance},
  author={E. J. Richards},
  journal={Nature Reviews Genetics},
  year={2006},
  volume={7},
  pages={395-401}
}
  • E. J. Richards
  • Published 2006
  • Biology, Medicine
  • Nature Reviews Genetics
  • Phenotypic variation is traditionally parsed into components that are directed by genetic and environmental variation. The line between these two components is blurred by inherited epigenetic variation, which is potentially sensitive to environmental inputs. Chromatin and DNA methylation-based mechanisms mediate a semi-independent epigenetic inheritance system at the interface between genetic control and the environment. Should the existence of inherited epigenetic variation alter our thinking… CONTINUE READING
    959 Citations

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Epigenetic Variations in Heredity and Evolution
    • E. Jablonka
    • Biology, Medicine
    • Clinical pharmacology and therapeutics
    • 2012
    • 48
    Epigenetic variation and inheritance in mammals.
    • V. Rakyan, S. Beck
    • Biology, Medicine
    • Current opinion in genetics & development
    • 2006
    • 83
    A quantitative genetic and epigenetic model of complex traits
    • 11
    • PDF
    Epigenome dynamics: a quantitative genetics perspective
    • 188
    • PDF
    The Genetics of Epigenetic Inheritance: Modes, Molecules, and Mechanisms
    • 41
    How epigenetic mutations can affect genetic evolution: model and mechanism.
    • 168
    • Highly Influenced
    Molecular Mechanisms of Epigenetic Variation in Plants
    • 28
    • Highly Influenced
    • PDF
    Epigenetic inheritance: a contributor to species differentiation?
    • 15
    What Role Does Heritable Epigenetic Variation Play in Phenotypic Evolution?
    • 158
    • PDF

    References

    SHOWING 1-10 OF 76 REFERENCES
    The inheritance of epigenetic defects.
    • 961
    Epigenetic inheritance, genetic assimilation and speciation.
    • 142
    • PDF
    Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission
    • V. Rakyan, S. Chong, +4 authors E. Whitelaw
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 569
    • PDF
    Epigenetic inheritance in the mouse
    • 214
    The epigenetics of cancer etiology.
    • A. Feinberg
    • Biology, Medicine
    • Seminars in cancer biology
    • 2004
    • 331
    Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
    • 1,782
    • PDF