Inherited disorders of renal magnesium handling.

@article{Cole2000InheritedDO,
  title={Inherited disorders of renal magnesium handling.},
  author={David E. C. Cole and Gary A. Quamme},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 10},
  pages={1937-47}
}
The genetic basis and cellular defects of a number of primary magnesium wasting diseases have been elucidated over the past decade. This review correlates the clinical pathophysiology with the primary defect and secondary changes in cellular electrolyte transport. The described disorders include (1) hypomagnesemia with secondary hypocalcemia, an earlyonset, autosomal-recessive disease segregating with chromosome 9q12-22.2; (2) autosomal-dominant hypomagnesemia caused by isolated renal magnesium… CONTINUE READING