Inherited disorders of human Toll-like receptor signaling: immunological implications.

@article{Ku2005InheritedDO,
  title={Inherited disorders of human Toll-like receptor signaling: immunological implications.},
  author={Cheng-Lung Ku and Kun Yang and Jacinta Bustamante and Anne Puel and Horst von Bernuth and Orchid{\'e}e Filipe Santos and Tatiana C. Lawrence and Huey-Hsuan Chang and Hamoud A Al-Mousa and Capucine Picard and Jean-laurent Casanova},
  journal={Immunological reviews},
  year={2005},
  volume={203},
  pages={
          10-20
        }
}
In vitro nine of 10 known human Toll-like receptors (TLRs) are engaged by well-defined chemical agonists that mimic microbial compounds, raising the possibility that human TLRs play a critical role in protective immunity in vivo. We thus review here the recently described human primary immunodeficiencies caused by germline mutations in genes encoding molecules involved in cell signaling downstream from TLRs. Subjects with anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) carry… CONTINUE READING
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