Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

  title={Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study},
  author={Isabelle Cleynen and Gabrielle Boucher and Luke Jostins and Ludwig Philip Schumm and Sebastian Zeissig and Tariq Ahmad and Vibeke Andersen and J M Andrews and Vito Annese and Stephan Brand and Steven R Brant and Judy H Cho and Mark J. Daly and Marla Cindy Dubinsky and Richard H. Duerr and Lynnette Robin Ferguson and Andre Franke and R B Gearry and Philippe Goyette and Hakon Hakonarson and Jonas Halfvarson and Johannes R Hov and Hailang Huang and N A Kennedy and Limas Kup{\vc}inskas and Ian Craig Lawrance and James C. Lee and Jack Satsangi and Stephan Schreiber and Emilie Th{\'e}{\^a}tre and Andrea E. van der Meulen-de Jong and Rinse Karel Weersma and David C. Wilson and M. B. A. Parkes and S{\'e}verine Vermeire and John D Rioux and John C. Mansfield and Mark S. Silverberg and Graham L Radford-Smith and Dermot P. B. McGovern and Jeffrey C. Barrett and Charlie W. Lees},
  booktitle={The Lancet},
BACKGROUND Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further… CONTINUE READING
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  • XC Morgan, TL Tickle, H Sokol
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  • 2013

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