Inherited defects of thyroxine-binding proteins.

  title={Inherited defects of thyroxine-binding proteins.},
  author={Theodora Pappa and Alfonso Massimiliano Ferrara and Samuel Refetoff},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  volume={29 5},
Thyroid hormones (TH) are bound to three major serum transport proteins, thyroxine-binding globulin (TBG), transthyretin (TTR) and human serum albumin (HSA). TBG has the strongest affinity for TH, whereas HSA is the most abundant protein in plasma. Individuals harboring genetic variations in TH transport proteins present with altered thyroid function tests, but are clinically euthyroid and do not require treatment. Clinical awareness and early recognition of these conditions are important to… CONTINUE READING
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