Inherited congenital adrenal hyperplasia in the rabbit: absent cholesterol side-chain cleavage cytochrome P450 gene expression.

@article{Pang1992InheritedCA,
  title={Inherited congenital adrenal hyperplasia in the rabbit: absent cholesterol side-chain cleavage cytochrome P450 gene expression.},
  author={Songya Pang and Xinping Yang and Mingrong Wang and Ralph G. Tissot and Massimiliano Nino and Jose R Manaligod and Leslie P. Bullock and James Ian Mason},
  journal={Endocrinology},
  year={1992},
  volume={131 1},
  pages={181-6}
}
We investigated adrenal steroidogenic enzymes, their activity and mRNA expression, and in vitro biosynthesis of an enzyme in rabbits with congenital adrenal hyperplasia (CAH; weight: CAH, 19 +/- 5 mg/adrenal; normal, 2.7 +/- 1.0 mg/adrenal). Serum pregnenolone (delta 5-P) levels in CAH newborn rabbits (12-36 h) were normal (mean/range, 438/51-2191 ng/dl… CONTINUE READING