Inherited Predisposition to Spontaneous Preterm Delivery

@article{Bhattacharya2010InheritedPT,
  title={Inherited Predisposition to Spontaneous Preterm Delivery},
  author={Sohinee Bhattacharya and Edwin Amalraj Raja and Eider Ruiz Mirazo and Doris M. Campbell and Amanda Jane Lee and Jane E Norman and Siladitya Bhattacharya},
  journal={Obstetrics \& Gynecology},
  year={2010},
  volume={115},
  pages={1125-1133}
}
OBJECTIVE: To assess inherited predisposition to spontaneous preterm delivery. METHODS: In this retrospective cohort study, intergenerational data on deliveries in mother–daughter pairs were analyzed from the Aberdeen Maternity Neonatal Databank using multilevel logistic regression. The study included an exposed cohort of all women born spontaneously preterm or whose mothers had experienced at least one spontaneous preterm delivery (at 24–37 weeks of gestation). The unexposed cohort included… Expand
Recurrence of Preterm Delivery in Women with a Family History of Preterm Delivery
TLDR
The family history of preterm delivery is an independent risk factor forPreterm delivery in the next generation as well as one of the mother's sisters (F2 generation) being born preterm. Expand
Maternal risk factors for preterm birth: a country-based population analysis.
TLDR
It is demonstrated that there are peculiar risk factors for spontaneous PTB in the Italian population examined and an association between preterm delivery and certain maternal factors as: BMI, employment, previous abortions, previous PTBs and previous cesarean section is shown. Expand
Maternal race and intergenerational preterm birth recurrence
TLDR
An intergenerational effect of preterm birth among non‐Hispanic Black mothers but not non-Hispanic White mothers is found, and Black mothers born <34 weeks carry the highest risk of delivering their first child very preterm. Expand
Family history is a predictor of current preterm birth.
TLDR
Evidence that self-reported maternal family history is relevant in a US population cohort and across more distant generations than has previously been reported is provided, demonstrating the capacity for familial history to independently predict risk of spontaneous preterm birth even in the context of a negative personal history. Expand
Cross‐Generational Contributors to Preterm Birth in California: Singletons Based on Race/Ethnicity
TLDR
A cross‐generational risk of PTB that is consistent across race/ethnicity with hypertension as the only consistent risk factor is suggested. Expand
Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity.
TLDR
Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman. Expand
Incidence and outcome of preterm deliveries in Mother and Child Hospital Akure, Southwestern Nigeria
TLDR
To determine the incidence of preterm delivery in the Mother and Child Hospital, Akure, to investigate the outcome and explore the relationship between birth weight and neonatal survival, a large number of babies were preterm. Expand
Intergenerational Cohort Study of Preterm and Small-for-Gestational-Age Birth in Twins and Singletons
TLDR
A statistically significant interaction between twinning and mother's size for gestational age was identified in a multivariate linear regression analysis, indicating that singleton mothers born SGA were associated with a lower birth weight compared with mothers notBorn SGA. Expand
Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case–control study
TLDR
Traditional CVD risk factors are significantly associated with an increased risk of preterm birth; these findings reinforce the clinical importance of integrating obstetric and cardiovascular risk assessment across the healthcare continuum in women. Expand
Long-Term Infectious Morbidity of Premature Infants: Is There a Critical Threshold?
TLDR
Multivariate analysis found being born very or late to moderate preterm was independently associated with long-term infectious morbidity (adjusted hazard ratio (aHR) 1.5), and aHR 1.23, respectively, p < 0.001), while a comparable risk of long- term infectious morbidities was found in the two groups of premature births prior to 32 weeks gestation. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Familial patterns of preterm delivery: maternal and fetal contributions.
TLDR
Data suggest that paternal genes have little, if any, effect on preterm delivery risk, which argues against major contributions of fetal genes inherited from either parent. Expand
The Risk of Preterm Birth Across Generations
TLDR
An increased risk of preterm delivery exists for women who themselves were born before 37 weeks' gestation, and this risk is inversely correlated with the maternal gestational age at birth and is influenced by maternal age and parity. Expand
Current understanding of genetic factors in preterm birth
  • M. Varner, M. Esplin
  • Medicine
  • BJOG : an international journal of obstetrics and gynaecology
  • 2005
TLDR
Findings confirm a clear genetic predisposition to spontaneous preterm labour and preterm birth and raise hopes that patient‐specific therapies may be developed in the future. Expand
Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study
TLDR
The overall proportion of preterm deliveries increased significantly from 1995 to 2004 and primiparity and multiple birth were the most important contributing factors and the rise in spontaneous pre term deliveries in the standard population of primiparous women at low risk was greater than in the total population. Expand
The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth.
TLDR
It is suggested that the use of tests such as maternal serum alpha-fetoprotein, alkaline phosphatase, and granulocyte colony-stimulating factor as a group or adding their results to fetal fibronectin test and cervical length test results may enhance the ability to predict spontaneous preterm birth and that the development of a multiple-marker test for spontaneous pre term birth is feasible. Expand
Epidemiology and causes of preterm birth
TLDR
A short cervical length and a raised cervical-vaginal fetal fibronectin concentration are the strongest predictors of spontaneous preterm birth. Expand
Familial patterns in birth characteristics: impact on individual and population risks.
TLDR
Familial trends in gestational age and body proportions at birth were demonstrated; however, the relatively small population attributable risk per cents in Sweden are discussed. Expand
Epidemiology of preterm delivery in two birth cohorts with an interval of 20 years.
TLDR
Despite a favorable change in the distribution of most of these determinants over the 20 years, only a small part of the decrease of the total incidence of preterm delivery could be attributed to these changes, as a consistent and substantial reduction occurred in the incidence of spontaneous preterm birth in all categories of each single determinant. Expand
Rates of and factors associated with recurrence of preterm delivery.
TLDR
It is suggested that recurrence of preterm delivery contributes a notable portion of all preterm deliveries, especially at the shortest gestations, as well as factors associated with recurrence. Expand
Epidemiology of preterm birth
TLDR
Over the past 20-30 years advances in perinatal care have improved outcomes for infants born after short gestations, but there is still uncertainty and incomplete recording of estimates of gestation in developed countries. Expand
...
1
2
3
4
...