Inherited Predisposition to Spontaneous Preterm Delivery

  title={Inherited Predisposition to Spontaneous Preterm Delivery},
  author={Sohinee Bhattacharya and Edwin Amalraj Raja and Eider Ruiz Mirazo and Doris M. Campbell and Amanda J Lee and Jane E. Norman and Siladitya Bhattacharya},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To assess inherited predisposition to spontaneous preterm delivery. METHODS: In this retrospective cohort study, intergenerational data on deliveries in mother–daughter pairs were analyzed from the Aberdeen Maternity Neonatal Databank using multilevel logistic regression. The study included an exposed cohort of all women born spontaneously preterm or whose mothers had experienced at least one spontaneous preterm delivery (at 24–37 weeks of gestation). The unexposed cohort included… 

Recurrence of Preterm Delivery in Women with a Family History of Preterm Delivery

The family history of preterm delivery is an independent risk factor forPreterm delivery in the next generation as well as one of the mother's sisters (F2 generation) being born preterm.

Do adults born preterm deliver preterm babies? A record linkage study from Western Australia

  • R. SrinivasjoisAmanuel GebermedhinE. MalacovaG. Pereira
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2021
In Western Australia delivering a preterm child is 25% greater when the parent was born preterm than when theParent was born at term in Western Australia, and the effect appears to be transgenerational.

Maternal risk factors for preterm birth: a country-based population analysis.

Family history is a predictor of current preterm birth.

Maternal disease risk factors as predictors of preterm birth in California: a case-control study.

Traditional CVD risk factors are significantly associated with an increased risk of preterm birth; these findings reinforce the clinical importance of integrating obstetric and cardiovascular risk assessment across the healthcare continuum in women.

Cross‐Generational Contributors to Preterm Birth in California: Singletons Based on Race/Ethnicity

A cross‐generational risk of PTB that is consistent across race/ethnicity with hypertension as the only consistent risk factor is suggested.

Environmental risk factors and perinatal outcomes in preterm newborns, according to family recurrence of prematurity.

Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.

Incidence and outcome of preterm deliveries in Mother and Child Hospital Akure, Southwestern Nigeria

To determine the incidence of preterm delivery in the Mother and Child Hospital, Akure, to investigate the outcome and explore the relationship between birth weight and neonatal survival, a large number of babies were preterm.

Intergenerational Cohort Study of Preterm and Small-for-Gestational-Age Birth in Twins and Singletons

A statistically significant interaction between twinning and mother's size for gestational age was identified in a multivariate linear regression analysis, indicating that singleton mothers born SGA were associated with a lower birth weight compared with mothers notBorn SGA.

Maternal cardiovascular disease risk factors as predictors of preterm birth in California: a case–control study

Traditional CVD risk factors are significantly associated with an increased risk of preterm birth; these findings reinforce the clinical importance of integrating obstetric and cardiovascular risk assessment across the healthcare continuum in women.



Familial patterns of preterm delivery: maternal and fetal contributions.

Data suggest that paternal genes have little, if any, effect on preterm delivery risk, which argues against major contributions of fetal genes inherited from either parent.

The Risk of Preterm Birth Across Generations

Current understanding of genetic factors in preterm birth

  • M. VarnerM. Esplin
  • Medicine
    BJOG : an international journal of obstetrics and gynaecology
  • 2005
Findings confirm a clear genetic predisposition to spontaneous preterm labour and preterm birth and raise hopes that patient‐specific therapies may be developed in the future.

Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study

The overall proportion of preterm deliveries increased significantly from 1995 to 2004 and primiparity and multiple birth were the most important contributing factors and the rise in spontaneous pre term deliveries in the standard population of primiparous women at low risk was greater than in the total population.

The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth.

It is suggested that the use of tests such as maternal serum alpha-fetoprotein, alkaline phosphatase, and granulocyte colony-stimulating factor as a group or adding their results to fetal fibronectin test and cervical length test results may enhance the ability to predict spontaneous preterm birth and that the development of a multiple-marker test for spontaneous pre term birth is feasible.

Familial patterns in birth characteristics: impact on individual and population risks.

Familial trends in gestational age and body proportions at birth were demonstrated; however, the relatively small population attributable risk per cents in Sweden are discussed.

Epidemiology of preterm delivery in two birth cohorts with an interval of 20 years.

Despite a favorable change in the distribution of most of these determinants over the 20 years, only a small part of the decrease of the total incidence of preterm delivery could be attributed to these changes, as a consistent and substantial reduction occurred in the incidence of spontaneous preterm birth in all categories of each single determinant.

Rates of and factors associated with recurrence of preterm delivery.

It is suggested that recurrence of preterm delivery contributes a notable portion of all preterm deliveries, especially at the shortest gestations, as well as factors associated with recurrence.

Epidemiology of preterm birth

Over the past 20-30 years advances in perinatal care have improved outcomes for infants born after short gestations, but there is still uncertainty and incomplete recording of estimates of gestation in developed countries.