Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

  title={Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.},
  author={Richard M. Weinshilboum and F A Raymond},
  journal={American journal of human genetics},
  volume={29 2},
Catechol-O-methyltransferase activity was measured in blood obtained from 373 randomly selected subjects aged 16-18, 262 consecutive adult blood donors, and 201 first-degree relatives of subjects with RBC COMT activity of less than 8 U. The distribution of RBC COMT activity in a randoly selected populations was apparently bimodal with a nadir at approximately 8 U. Of a randomly selected population, 23% had low RBC COMT activity (less than 8 U), Because of previous reports of a significant… CONTINUE READING
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