Inheritance of cortical ER in yeast is required for normal septin organization

  title={Inheritance of cortical ER in yeast is required for normal septin organization},
  author={Christopher J. R. Loewen and Barry P. Young and Shabnam Tavassoli and Timothy P. Levine},
  journal={The Journal of Cell Biology},
  pages={467 - 483}
How cells monitor the distribution of organelles is largely unknown. In budding yeast, the largest subdomain of the endoplasmic reticulum (ER) is a network of cortical ER (cER) that adheres to the plasma membrane. Delivery of cER from mother cells to buds, which is termed cER inheritance, occurs as an orderly process early in budding. We find that cER inheritance is defective in cells lacking Scs2, a yeast homologue of the integral ER membrane protein VAP (vesicle-associated membrane protein… CONTINUE READING
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